PEmax mRNA (Cap1, m1Ψ)

The PEmax mRNA expresses an optimized prime editor enzymatic protein, which further increased editing efficiency in synergy with PE4, PE5 and engineered pegRNAs (Chen P, et al. 2021, Cell 184, 5635-5652). This mRNA is capped with Cap1-AG structure with high capping efficiency. It has 100% substituted with N1-methylpseudouridine for enhanced expression and reduced immunogenicity. The mRNA has a 100A tail in its sequence. After efficient delivery, PEmax mRNA can translate into protein including a nickase and reverse transcriptase function for gene editing in cells.

产物编号	RP-A00045
规格	0.1 mg 0.2 mg 1 mg 大单询价
数量
价格	￥1000


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产物介绍

产物介绍	The PEmax mRNA expresses an optimized prime editor enzymatic protein, which further increased editing efficiency in synergy with PE4, PE5 and engineered pegRNAs (Chen P, et al. 2021, Cell 184, 5635-5652). After efficient delivery into cells or animals, PEmax mRNA can translate into protein including a nickase and reverse transcriptase function for gene editing in cells. This mRNA is capped with Cap1-AG structure with high capping efficiency. It has 100% substituted with N1-methylpseudouridine for enhanced expression and reduced immunogenicity. The mRNA has a ~100A tail in its sequence, mimics a mature mRNA
产物浓度	1mg/mL
存储溶液	1mM Sodium citrate, pH6.5
尘搁狈础序列全长	6660nt
尘搁狈础全长分子量	2.15 X 10^6 Da
储存条件	Store at -20°C for short term (<3 months), store at -80°C for long term.