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PD-1 Fc Chimera, Human

PD-1 Fc Chimera, Human

PD-1 Fc Chimera, Human

Immobilized PD-L1-His,Human(Cat.No.Z03425) at 2 μg/mL (100 μL/well) can bind PD-1, Fc,Humanwith a linear range of 0.024-0.39μg/mL.

PD-1 Fc Chimera, Human

GenScript product showed equal activity compared to competitor A.

PD-1 Fc Chimera, Human

Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279) or PDCD1, is a protein that in humans is encoded by the PDCD1 gene. PD-1 is a cell surface receptor that belongs to the immunoglobulin superfamily and is expressed on T cells and pro-B cells.PD-1 binds two ligands, PD-L1 and PD-L2. PD-1 and its ligands play an important role in down regulating the immune system by preventing the activation of T-cells, which in turn reduces autoimmunity and promotes self-tolerance. The inhibitory effect of PD-1 is accomplished through a dual mechanism of promoting apoptosis (programmed cell death) in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in regulatory T cells (suppressor T cells)
Z03370
￥960

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产物介绍
Species Human
Protein Construction
PD-1 (Leu25-Gln167)
Accession # Q15116		 hFc
N-term C-term
Purity > 98% as analyzed by SDS-PAGE
Endotoxin Level < 0.2 EU/μg of protein by gel clotting method
Biological Activity Assay #1: Immobilized PD-L1, hFc, Human (Cat. No.: Z03371) at 1.0 μg/ml (100 μl/well) can bind biotinylated PD-1, hFc, Human.
Assay #2: Immobilized PD-L1, His, Human(Cat. No.: Z03425) at 2.0 μg/ml (100 ?l/well) can bind PD-1, hFc, Human.
Expression System CHO
Apparent Molecular Weight 60~65 kDa, on SDS-PAGE under reducing conditions.
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH?O or PBS up to 100 μg/ml.
Storage & Stability Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

图例
  • PD-1 Fc Chimera, Human
    • PD-1 Fc Chimera, Human

  • PD-1 Fc Chimera, Human
    • PD-1 Fc Chimera, Human

  • PD-1 Fc Chimera, Human
    • PD-1 Fc Chimera, Human

    Immobilized PD-L1-His,Human(Cat.No.Z03425) at 2 μg/mL (100 μL/well) can bind PD-1, Fc,Humanwith a linear range of 0.024-0.39μg/mL.

  • PD-1 Fc Chimera, Human
    • PD-1 Fc Chimera, Human

    GenScript product showed equal activity compared to competitor A.


技术背景
Target Background Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279) or PDCD1, is a protein that in humans is encoded by the PDCD1 gene. PD-1 is a cell surface receptor that belongs to the immunoglobulin superfamily and is expressed on T cells and pro-B cells.PD-1 binds two ligands, PD-L1 and PD-L2. PD-1 and its ligands play an important role in down regulating the immune system by preventing the activation of T-cells, which in turn reduces autoimmunity and promotes self-tolerance. The inhibitory effect of PD-1 is accomplished through a dual mechanism of promoting apoptosis (programmed cell death) in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in regulatory T cells (suppressor T cells)
Synonyms PD-1; CD279; PDCD1; Programmed cell death 1

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.


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