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目录产物 » 重组蛋白 » CD25/IL-2Rα, hFc, Human
CD25/IL-2Rα Fc Chimera, Human

CD25/IL-2Rα Fc Chimera, Human

Immobilized IL-2,Human (Cat.No.Z03074) at 5μg/mL (100 μL/well) can bind CD25/IL-2Rα, Fc Chimera,Human with a linear range of 1.2-11 ng/mL.

CD25/IL-2Rα Fc Chimera, Human

The IL-2 receptor system consists of three non-covalently linked subunits termed IL-2Rα, IL-2Rβ, and IL-2Rγ. The IL-2Rα is a type I transmembrane protein consisting of a 219 amino acid (a.a.) extracellular domain, a 19 a.a. transmembrane domain and a 13 a.a. intracellular domain, which is not involved in the transduction of IL-2 signal. Activated T cells, regulatory T cells (Tregs) and NK cells express high levels of CD25 and expression of the high-affinity IL-2Rα is mostly limited to these cell populations. Signaling via IL-2Rα mediates multiple biological processes in various cell populations, e.g. proliferation and differentiation of B cells and NK cells. A soluble form of IL-2Rα (IL-2Rα) appears in serum, concomitant with its increased expression on cells. The function of the soluble IL-2Rα is unclear. Increased levels of IL-2Rα in biological fluids reportedly correlate with increased T and B cell activation and immune system activation. Increased serum concentration of IL-2Rα has been observed in patients with a variety of inflammatory conditions and in the course of some leukemias and lymphomas.
Z03400
￥1200

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产物介绍
Species Human
Protein Construction
CD25/IL-2Rα (Glu22-Cys213)
Accession # P01589		 hFc
N-term C-term
Purity > 95% as analyzed by SDS-PAGE
Endotoxin Level < 0.2 EU/μg of protein by gel clotting method
Biological Activity Immobilized Human IL-2 at 5.0 μg/ml (100 ?l/well) can bind CD25/IL-2Rα, hFc, Human.
Expression System HEK 293
Apparent Molecular Weight 65~75 kDa, on SDS-PAGE under reducing conditions.
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH?O or PBS up to 100 μg/ml.
Storage & Stability Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

图例
  • CD25/IL-2Rα Fc Chimera, Human
    • CD25/IL-2Rα Fc Chimera, Human

  • CD25/IL-2Rα Fc Chimera, Human
    • CD25/IL-2Rα Fc Chimera, Human

    Immobilized IL-2,Human (Cat.No.Z03074) at 5μg/mL (100 μL/well) can bind CD25/IL-2Rα, Fc Chimera,Human with a linear range of 1.2-11 ng/mL.


技术背景
Target Background The IL-2 receptor system consists of three non-covalently linked subunits termed IL-2Rα, IL-2Rβ, and IL-2Rγ. The IL-2Rα is a type I transmembrane protein consisting of a 219 amino acid (a.a.) extracellular domain, a 19 a.a. transmembrane domain and a 13 a.a. intracellular domain, which is not involved in the transduction of IL-2 signal. Activated T cells, regulatory T cells (Tregs) and NK cells express high levels of CD25 and expression of the high-affinity IL-2Rα is mostly limited to these cell populations. Signaling via IL-2Rα mediates multiple biological processes in various cell populations, e.g. proliferation and differentiation of B cells and NK cells. A soluble form of IL-2Rα (IL-2Rα) appears in serum, concomitant with its increased expression on cells. The function of the soluble IL-2Rα is unclear. Increased levels of IL-2Rα in biological fluids reportedly correlate with increased T and B cell activation and immune system activation. Increased serum concentration of IL-2Rα has been observed in patients with a variety of inflammatory conditions and in the course of some leukemias and lymphomas.
Synonyms CD25 antigen; CD25; IDDM10; IL-2 R alpha; IL-2Rα

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.


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