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目录产物 » CD27 Ligand/CD70, hFc, Human
CD27 Ligand/CD70 Fc Chimera, Human

CD27 Ligand/CD70 Fc Chimera, Human

CD27 Ligand/CD70 Fc Chimera, Human

Immobilized CD27 (Mammalian,C-Fc-6His) at 1 ?g/ml (100 μl/well) can bind CD27 Ligand/CD70 Chimera, Human with EC50=18.33 ng/ml when detected by SA-HRP. Background was subtracted from data points before curve fitting.

CD27 Ligand/CD70 Fc Chimera, Human

CD70 (Cluster of Differentiation 70) is a protein that in humans is encoded by CD70 gene. CD70 is a ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.The CD70 protein is expressed on highly activated lymphocytes (like in T- and B-cell lymphomas). It is therefore suggested that anti-CD70 antibodies might be a possible treatment for CD70 positive lymphomas as normal lymphocytes have low CD70 expression.
Z03450
￥1760

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产物介绍
Species Human
Protein Construction
CD70 (Gln39-Pro193)
Accession # P32970		 hFc
N-term C-term
Purity > 95% as analyzed by SDS-PAGE
Endotoxin Level < 1 EU/μg of protein by gel clotting method
Biological Activity Immobilized CD27 (Mammalian, C-Fc-6His) at 1.0 ?g/ml (100 μl/well) can bind CD27 Ligand/CD70, hFc, Human with EC50=18.33 ng/ml when detected by SA-HRP.
Expression System HEK 293
Apparent Molecular Weight ~53.6 kDa, on SDS-PAGE under reducing conditions.
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH?O or PBS up to 100 μg/ml.
Storage & Stability Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

图例
  • CD27 Ligand/CD70 Fc Chimera, Human
    • CD27 Ligand/CD70 Fc Chimera, Human

  • CD27 Ligand/CD70 Fc Chimera, Human
    • CD27 Ligand/CD70 Fc Chimera, Human

  • CD27 Ligand/CD70 Fc Chimera, Human
    • CD27 Ligand/CD70 Fc Chimera, Human

    Immobilized CD27 (Mammalian,C-Fc-6His) at 1 ?g/ml (100 μl/well) can bind CD27 Ligand/CD70 Chimera, Human with EC50=18.33 ng/ml when detected by SA-HRP. Background was subtracted from data points before curve fitting.


技术背景
Target Background CD70 (Cluster of Differentiation 70) is a protein that in humans is encoded by CD70 gene. CD70 is a ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.The CD70 protein is expressed on highly activated lymphocytes (like in T- and B-cell lymphomas). It is therefore suggested that anti-CD70 antibodies might be a possible treatment for CD70 positive lymphomas as normal lymphocytes have low CD70 expression.
Synonyms CD27-L; CD_antigen: CD70; CD27L; CD27LG; TNFSF7

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.


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