DNAM-1/CD226 Fc Chimera, Human

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目录产物 » DNAM-1/CD226, hFc, Human

Immobilized Rhesus macaque CD155/PVR Protein, His Tag at 1 μg/ml (100 μl/well) can bind DNAM-1/CD226 Fc Chimera, Human with an EC50 of 0.871 μg/ml when detected by Mouse Anti–Human IgG Fc-HRP. Background was subtracted from data points before curve fitting.

DNAM-1 (DNAX accessory molecule-1), also known as CD226, platelet and T cell activation antigen 1 (PTA1) and TLiSA1, is a member of the Ig superfamily containing two Ig-like domains of the V set and is encoded by a gene on human chromosome 18q22.3. DNAM-1 is an activating receptor expressed on natural killer (NK) cells, CD8+ T cells, and other immune cells. Upon recognition of its ligands, CD155 and CD112, DNAM-1 promotes NK cell–mediated elimination of transformed and virus-infected cells. It also has a key role in expansion and maintenance of virus-specific memory NK cells. DNAM-1 is the cell surface receptor of NECTIN2. Upon ligand binding, it stimulates T cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13 and IFNG.

产物编号	Z03454
规格	10 μg 50 μg 1 mg 大单询价
数量
价格	￥320


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产物介绍

Species

Human

Protein Construction

DNAM-1/CD226 (Glu19-Asn247) Accession # Q15762	hFc
N-term	C-term

Purity

> 95% as analyzed by SDS-PAGE

Endotoxin Level

< 1 EU/μg of protein by gel clotting method

Biological Activity

Immobilized Rhesus macaque CD155/PVR Protein, His Tag at 1.0 μg/ml (100 μl/well) can bind DNAM-1/CD226, hFc, Human with an EC₅₀ of 0.871 μg/ml when detected by Mouse Anti-Human IgG Fc-HRP.

Expression System

HEK 293

Apparent Molecular Weight

~81.7 kDa, on SDS-PAGE under reducing conditions.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS.

Reconstitution

It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH?O or PBS up to 100 μg/ml.

Storage & Stability

Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

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