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目录产物 » CDH17/Cadherin 17, His, Cynomolgus
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CDH17/Cadherin 17, His, Cynomolgus

Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
￥3800
Z04763-100

产物介绍
Species Cynomolgus
Protein Construction
CDH17/Cadherin 17 (Gln23-Thr784)
Accession # XP_005563762.2		 His
N-term C-term
Purity > 95%?as?determined?by?Bis?Tris?PAGE?
> 90%?as?determined?by?HPLC
Endotoxin Level Less than 1 EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized CDH17/Cadherin 17, His, Cynomolgus at 1μg/ml (100μl/well) on the plate can bind Anti?CDH17 Antibody, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 85.57 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 95-115 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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技术背景
Target Background Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
Synonyms Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1; cadherin-16
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.