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目录产物 » BAFFR/TNFRSF13C, His, Human
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BAFFR/TNFRSF13C, His, Human

BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL (a proliferation-inducing ligand), BAFF R selectively binds BAFF.
￥3800
Z05072-100

产物介绍
Species Human
Protein Construction
BAFFR/TNFRSF13C (Ser7-Ala71)
Accession # Q96RJ3-1		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized BAFFR/TNFRSF13C, His, Human at 2 μg/ml (100 μl/well) on the plate can bind Biotinylated Human BAFF, His Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 7.6 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 13-25 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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图例
BAFFR/TNFRSF13C, His, Human

Immobilized BAFFR/TNFRSF13C, His, Human, His Tag at 2 μg/ml(100 μl/well) on the plate. Dose response curve for Biotinylated Human BAFF, His Avi Tag with the EC50 of 7.3 ng/ml determined by ELISA. ?

BAFFR/TNFRSF13C, His, Human

BAFFR/TNFRSF13C, His, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%. ?

BAFFR/TNFRSF13C, His, Human

Immobilized BAFFR/TNFRSF13C, His, Human, His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-BAFFR Antibody, hFc Tag with the EC50 of 6.2ng/ml determined by ELISA. ?

BAFFR/TNFRSF13C, His, Human

BAFFR/TNFRSF13C, His, Human on CM5 Chip via anti-his antibody can bind Human BAFF Trimer, hFc-Flag Tag with an affinity constant of 1.21 nM as determined in SPR assay (Biacore T200). ?

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技术背景
Target Background BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL (a proliferation-inducing ligand), BAFF R selectively binds BAFF.
Synonyms CD268; BAFFR; BR3; TNFRSF13C; BROMIX; CVID4; prolixin
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.