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BST2, His, Human

Interferon-induced BST2 (bone marrow stromal cell antigen 2) inhibits viral replication by tethering enveloped virions to the cell surface to restrict viral release and by inducing the NFKB-dependent antiviral immune response. BST2 expression was significantly increased during porcine epidemic diarrhea virus (PEDV) infection of Vero cells by IRF1 targeting its promoter. Both the BST2 and N protein interacted with the E3 ubiquitin ligase MARCHF8/MARCH8 and the cargo receptor.
￥3000
Z05086-100

产物介绍
Species Human
Protein Construction
His BST2 (Asn49-Ser161)
Accession # Q10589-1
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized BST2, His, Human at 2μg/ml (100μl/Well) on the plate can bind Anti?BST2 Antibody, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 14.5 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 25-35 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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图例
BST2, His, Human

Immobilized BST2, His, Human, His Tag at 2 μg/ml(100 μl/well) on the plate. Dose response curve for Anti-BST2 Antibody, hFc Tag with the EC50 of 4.0 ng/ml determined by ELISA. ?

BST2, His, Human

BST2, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. ?

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技术背景
Target Background Interferon-induced BST2 (bone marrow stromal cell antigen 2) inhibits viral replication by tethering enveloped virions to the cell surface to restrict viral release and by inducing the NFKB-dependent antiviral immune response. BST2 expression was significantly increased during porcine epidemic diarrhea virus (PEDV) infection of Vero cells by IRF1 targeting its promoter. Both the BST2 and N protein interacted with the E3 ubiquitin ligase MARCHF8/MARCH8 and the cargo receptor.
Synonyms BST-2; HM1.24 antigen; CD317; BST2; NPC-A-7; PDCA-1; TETHERIN
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.