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目录产物 » CDH17/Cadherin 17 Domain 1-6, His, Human
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CDH17/Cadherin 17 Domain 1-6, His, Human

Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
￥4300
Z05148-100

产物介绍
Species Human
Protein Construction
CDH17/Cadherin 17 Domain 1-6 (Gln23-Leu667)
Accession # Q12864		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized CDH17/Cadherin 17 Domain 1-6, His, Human at 1μg/ml (100μl/Well) on the plate can bind Anti?CDH17 Anitibody, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 72.90 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 90-110 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in 20mM Tris, 150mM NaCl (pH 8.0).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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图例
CDH17/Cadherin 17 Domain 1-6, His, Human

Immobilized CDH17/Cadherin 17 Domain 1-6, His, Human, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 8.9 ng/ml determined by ELISA. ?

CDH17/Cadherin 17 Domain 1-6, His, Human

CDH17/Cadherin 17 Domain 1-6, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. ?

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技术背景
Target Background Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
Synonyms Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1; cadherin-16; FLJ26931; MGC138218; MGC142024
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.