9I果冻制作厂官网

目录产物 » Clusterin, His, Human
Manual
SDS
COAs

Clusterin, His, Human

Clusterin (CLU) is a stress-activated, ATP-independent molecular chaperone, normally secreted from cells, that is up-regulated in Alzheimer disease and in many cancers. It plays important roles in protein homeostasis/proteostasis, inhibition of cell death pathways, and modulation of pro-survival signalling and transcriptional networks. Changes in the CLU gene locus are highly associated with Alzheimer disease, and many therapy-resistant cancers over-express CLU.
￥3000
Z05182-100

产物介绍
Species Human
Protein Construction
Clusterin (Asp23-Glu449)
Accession # P10909-1		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Clusterin, His, Human at 1μg/ml (100μl/well) on the plate can bind Anti?Clusterin Antibody, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 51.2 kDa
Apparent Molecular Weight The protein migrates to 38-41 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
返回

图例
Clusterin, His, Human

Immobilized Clusterin, His, Human, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-Clusterin Antibody, hFc Tag with the EC50 of 9.0 ng/ml determined by ELISA. ?

Clusterin, His, Human

Clusterin, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. ?

<
>

技术背景
Target Background Clusterin (CLU) is a stress-activated, ATP-independent molecular chaperone, normally secreted from cells, that is up-regulated in Alzheimer disease and in many cancers. It plays important roles in protein homeostasis/proteostasis, inhibition of cell death pathways, and modulation of pro-survival signalling and transcriptional networks. Changes in the CLU gene locus are highly associated with Alzheimer disease, and many therapy-resistant cancers over-express CLU.
Synonyms Clusterin; Apo-J; Clustrin; SGP-2; Msgp-2; CLU; AAG4; APOJ; CLI; KUB1; SP-40; TRPM2; CLI; KUB1;
返回

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.