| ￥4100 | |
| Z05532-100 | |
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| Species | Human | ||||||
| Protein Construction |
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| Purity |
> 95%?as?determined?by?Bis?Tris?PAGE? > 95%?as?determined?by?HPLC |
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| Endotoxin Level | Less than 1 EU per μg by the LAL method. | ||||||
| Biological Activity | Measured by its binding ability in a functional ELISA. Immobilized Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer, His & Avi, Human at 2 μg/ml (100μl/well) on the plate can bind Biotinylated Human Latent TGF beta 1, His Tag. Test result was comparable to standard batch. | ||||||
| Expression System | HEK293 | ||||||
| Theoretical Molecular Weight | 114 kDa (ITGAV)&79.1 kDa (ITGB6) | ||||||
| Apparent Molecular Weight | Due to glycosylation, the protein migrates to 90-150 kDa based on Bis-Tris PAGE result. | ||||||
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). | ||||||
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. | ||||||
| Storage & Stability | Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles. |
| Target Background | ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV&ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. |
| Synonyms | αVβ6; Integrin alpha V beta 6; ITGAV&ITGB6;Integrin alpha V β 6 |
For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.
