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MICA alpha 3 mFc Chimera, Human

MICA (MHC class I chain-related gene A) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. A closely related protein, MICB, shares 85% amino acid identity with MICA. These proteins are distantly related to the MHC class I proteins. They possess three extracellular Ig?like domains, but they have no capacity to bind peptide or interact with beta 2-microglobulin.
¥4100
Z05647-100

Species Human
Protein Construction
mFc (IgG1) MICA alpha 3 (Arg105-Ser200)_x000D_
Accession # NP_001276081.1
N-term C-term
Purity >?95%?as?determined?by?Bis?Tris?PAGE?
> 95%?as?determined?by?HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized MICA alpha 3 mFc Chimera, Human at 2μg/ml (100μl/well) on the plate can bind Anti?MICA Antibody, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 36.8 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 50-65 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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Target Background MICA (MHC class I chain-related gene A) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. A closely related protein, MICB, shares 85% amino acid identity with MICA. These proteins are distantly related to the MHC class I proteins. They possess three extracellular Ig?like domains, but they have no capacity to bind peptide or interact with beta 2-microglobulin.
Synonyms MICA; MIC-A; MICA alpha 3
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.