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目录产物 » Siglec-10 (R119A), His & Avi, Human
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Siglec-10 (R119A), His & Avi, Human

Siglec-10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab. It is also reported to bind to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24 also known as HSA (Heat-stable antigen).Siglecs (sialic acid binding Ig-like lectins) are I-type lectins that belong to the immunoglobulin superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by a varying number of Ig-like C2-type domains. Siglecs 5-11 constitute the CD33/Siglec-3 related group, and are differentially expressed in the hematopoietic system.
￥3500
Z05816-100

产物介绍
Species Human
Protein Construction
Siglec-10 (R119A) (Met17-Thr546)_x000D_
Accession # Q96LC7-1		 His Avi
N-term C-term
Purity >?95%?as?determined?by?Bis?Tris?PAGE
>?95%?as?determined?by?HPLC
Endotoxin Level Less than 1EU per ug by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Siglec-10 (R119A), His & Avi, Human at 1μg/ml (100μl/well) on the plate can bind Anti?Siglec?10 (R119A) Antibody, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 62.64 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 65-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in 20mM Tris,150mM NaCl, 200mM Arginine (pH 8.0).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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技术背景
Target Background Siglec-10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab. It is also reported to bind to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24 also known as HSA (Heat-stable antigen).Siglecs (sialic acid binding Ig-like lectins) are I-type lectins that belong to the immunoglobulin superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by a varying number of Ig-like C2-type domains. Siglecs 5-11 constitute the CD33/Siglec-3 related group, and are differentially expressed in the hematopoietic system.
Synonyms SLG2; SIGLEC10; MGC126774; PRO940
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.