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Midkine, His, Mouse

Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue homeostasis and disease development. Midkine is abnormally expressed at high levels in various human malignancies and acts as a mediator for the acquisition of critical hallmarks of cancer, including cell growth, survival, metastasis, migration, and angiogenesis.
￥3300
Z06270-100

产物介绍
Species Mouse
Protein Construction
His Midkine (Lys23-Asp140)_x000D_
Accession # P12025
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System E.coli
Theoretical Molecular Weight 14.03 kDa
Apparent Molecular Weight The protein migrates to 18?23 kDa based on Bis?Tris PAGE result.
Formulation Supplied as 0.22μm filtered solution in PBS, 350mM NaCl, 200mM L-arginine (pH 7.4).
Concentration Verified by one or more methods from 0.64mg/ml A280/Bioactivity/BCA/Bradford.
Storage & Stability This product remains stable for 6 months at -80°C or below. Avoid repeated freeze-thaw cycles.
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技术背景
Target Background Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue homeostasis and disease development. Midkine is abnormally expressed at high levels in various human malignancies and acts as a mediator for the acquisition of critical hallmarks of cancer, including cell growth, survival, metastasis, migration, and angiogenesis.
Synonyms MK; ARAP; MDK; MEK; MK1; MKARAP; NEGF2
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.