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至今,GenScript的服务及产物已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

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A bistable autoregulatory module in the developing embryo commits cells to binary expression fates
Authors: Jiaxi Zhao, Mindy Liu Perkins, Matthew Norstad, Hernan G Garcia
Journal: Curr Biol
PubMed ID: 37453424
Doi: 10.1016/j.cub.2023.06.060
An intermediate state allows influenza polymerase to switch smoothly between transcription and replication cycles
Authors: Huanhuan Li, Yixi Wu, Minke Li, Lu Guo, Yaqi Gao, Quan Wang, Jihua Zhang, Zhaohua Lai, Xing Zhang, Lixin Zhu, Ping Lan, Zihe Rao, Yingfang Liu, Huanhuan Liang
Journal: Nat Struct Mol Biol
PubMed ID: 37488357
Doi: 10.1038/s41594-023-01043-2
TLR5S negatively regulates the TLR5M-mediated NF-κB signaling pathway in Epinephelus coioides
Authors: Liangge He, Xue Yu, Yulin Zhao, Haoran Lin, Yong Zhang, Danqi Lu
Journal: Int J Biol Macromol
PubMed ID: 37517756
Doi: 10.1016/j.ijbiomac.2023.126048
Tumor Site-Specific Cleavage Improves the Antitumor Efficacy of Antibody-Drug Conjugates
Authors: Keyuan Xu, Jiani Han, Liu Yang, Li Cao, Shuang Li, Zhangyong Hong
Journal: Int J Mol Sci
PubMed ID: 37446189
Doi: 10.3390/ijms241311011
Hypoxic papillary thyroid carcinoma cells-secreted exosomes deliver miR-221-3p to normoxic tumor cells to elicit a pro-tumoral effect by regulating the ZFAND5
Authors: Fan Yu, Xianzhao Deng, Yong Zhong, Bomin Guo, Xiaoping Zhang, Bo Wu
Journal: Exp Cell Res
PubMed ID: 37488006
Doi: 10.1016/j.yexcr.2023.113716
Structural Basis for the Ribonuclease Activity of a Thermostable CRISPR-Cas13a from Thermoclostridium caenicola
Authors: Feng Wang, Chendi Zhang, Haijiang Xu, Wanting Zeng, Lixin Ma, Zhuang Li
Journal: J Mol Biol
PubMed ID: 37442412
Doi: 10.1016/j.jmb.2023.168197
Antibody Fc-binding profiles and ACE2 affinity to SARS-CoV-2 RBD variants
Authors: Ebene R Haycroft, Samantha K Davis, Pradhipa Ramanathan, Ester Lopez, Ruth A Purcell, Li Lynn Tan, Phillip Pymm, Bruce D Wines, P Mark Hogarth, Adam K Wheatley, Jennifer A Juno, Samuel J Redmond, Nicholas A Gherardin, Dale I Godfrey, Wai-Hong Tham, Kevin John Selva, Stephen J Kent, Amy W Chung
Journal: Med Microbiol Immunol
PubMed ID: 37477828
Doi: 10.1007/s00430-023-00773-w
Fusion of Substrate-Binding Domains Enhances the Catalytic Capacity of Keratinases and Promotes Enzymatic Conversion of Feather Waste
Authors: Xiaomei Ji, Zheng Peng, Jie Song, Guoqiang Zhang, Juan Zhang
Journal: J Agric Food Chem
PubMed ID: 37462367
Doi: 10.1021/acs.jafc.3c03064
Structural insights into RNA bridging between HIV-1 Vif and antiviral factor APOBEC3G
Authors: Takahide Kouno, Satoshi Shibata, Megumi Shigematsu, Jaekyung Hyun, Tae Gyun Kim, Hiroshi Matsuo, Matthias Wolf
Journal: Nat Commun
PubMed ID: 37419875
Doi: 10.1038/s41467-023-39796-5
Polypeptide Substrate Accessibility Hypothesis: Gain-of-Function R206H Mutation Allosterically Affects Activin Receptor-like Protein Kinase Activity
Authors: Jay C Groppe, Guorong Lu, Mary R Tandang-Silvas, Anupama Pathi, Shruti Konda, Jingfeng Wu, Viet Q Le, Andria L Culbert, Eileen M Shore, Kristi A Wharton, Frederick S Kaplan
Journal: Biomolecules
PubMed ID: 37509165
Doi: 10.3390/biom13071129

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